What is a normal DLCO?
A Dlco within the normal range (75% to 140% predicted) cannot completely rule out lung disease when the patient is persistently and genuinely dyspneic.
What does low DLCO indicate?
DLCO values represent the ability of the lung to transfer gas from the inhaled air into the blood stream and acts as a surrogate marker of the extent of lung damage (1). DLCO values may decrease because of several clinical conditions including emphysema, interstitial lung diseases, or pulmonary fibrosis (2).
What does DLCO Va mean?
Abbreviations. DLCO. diffusing capacity of the lung for carbon monoxide. DLCO/VA. diffusing capacity of the lung for carbon monoxide divided by alveolar volume.
What causes increased DLCO?
In clinical practice, the most common causes of an elevated DLCO are obesity and asthma, which are largely attributable to the higher resting cardiac outputs and resultant greater pulmonary capillary bed recruitment.
Can DLCO improve?
Conclusion: Pulmonary rehabilitation improves oxygenation, severity of dyspnea, exercise capasity and quality of life independent of carbon monoxide diffusion capacity in patents with COPD. Improvement in DLCO in patients with severe diffusion defect suggests that pulmonary rehabilitation reduced mortality.
Does exercise improve DLCO?
In exercise, both the ventilatory and cardiovascular systems are tested, which can explain observa- tions that exercise variables are predictive of cardiopulmonary complications and mortality. DLCO increases during exercise, but may not increase adequately if the pulmonary vascular bed is reduced by emphysema.
What causes decreased DLCO?
There are several conditions that can decrease the DLCO. These include cigarette smoking, emphysema, interstitial lung disease, anemia, decreased lung volume, heart failure, pulmonary vascular disease (pulmonary emboli and pulmonary hypertension), and others.
What is DLCO in COPD?
DLCO. The diffusing capacity of the lung for carbon monoxide (DLCO) is a measure of how easily carbon monoxide (CO) molecules transfer from the alveolar gas to the hemoglobin of the red cells in the pulmonary circulation. In COPD, the DLCO decreases with increasing severity of disease.
What is DLCO used for?
It is also known as the transfer factor.  DLCO is a measurement to assess the ability of the lungs to transfer gas from inspired air to the bloodstream.
What does a high DLCO mean?
Conclusion: A high DLCO on a PFT is most frequently associated with large lung volumes, obesity, and asthma. Other conditions are much less common. A clinical condition, which typically reduces DLCO, may deceptively normalize DLCO in such patients.
What affects DLCO?
Physiologically, there are factors that affect the value of DLCO and they can complicate interpretation of the test. One of these factors is increased pulmonary blood flow, which can increase the value of DLCO. This occurs in exercise, via the recruitment of new pulmonary capillaries.
What is DLCO SB?
The single-breath diffusing capacity of the lung for CO [DLCO(SB)] is considered a measure of the conductance of CO across the alveolar-capillary membrane and its binding with hemoglobin.