Calvert equation
What is Calvert formula?
Calvert Equation1 • Carboplatin Dose (mg) = Target area under the curve (AUC mg∙min/mL) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).
How do you calculate AUC carboplatin?
Background InfoCALVERT FORMULA FOR CARBOPLATIN DOSING: Total Dose (mg) = (target AUC) x (GFR + 25) AUC = target area under the concentration versus time curve in mg/mL•min.GFR was measured by 51Cr-EDTA clearance. Relevant package insert data:
What is AUC in carboplatin?
AUC is the “area under the curve” – a figure that reflects the concentration of drug in the body that doctors want to achieve; GFR is the glomerular filtration rate – the rate at which an individual patient’s kidneys work; A is the ratio of this glomerular filtration rate to how quickly the kidneys get rid of
What is AUC in chemotherapy?
The most relevant pharmacokinetic parameter for drug exposure is the area under the curve (AUC) of plasma concentration x time following a single dose. During drug development, drug level sampling at multiple time points helps define the relationship between drug administration and the AUC.
How is kidney function calculated?
eGFR – Estimated glomerular filtration rate is the best test to measure your level of kidney function and determine your stage of kidney disease. Your doctor can calculate it from the results of your blood creatinine test, your age, body size and gender.
What does AUC stand for?
area under the curve
How do you calculate ideal body weight?
Ideal body weight is computed in men as 50 + (0.91 × [height in centimeters − 152.4]) and in women as 45.5 + (0.91 × [height in centimeters − 152.4]). A simple alternative would be to compute ideal body weight as the weight corresponding to an ideal body mass index of 22 kg/m2.
How do we calculate GFR?
eGFR is estimated GFR calculated by the abbreviated MDRD equation : 186 x (Creatinine/88.4)–1.154 x (Age)–0.203 x (0.742 if female) x (1.210 if black). If you have an eGFR value calculated by a local laboratory, use that.
What are the units of AUC?
The unit of AUC is the unit of time multiplied by the unit of radioactivity concentration, usually min*kBq/mL. The AUC from 0 to infinite time, AUC–∞, can be used to estimate the total clearance of radiopharmaceuticals, CIT.
What is a good AUC score?
The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.
How is target AUC calculated?
In this article, the development and application of a simple equation, known as the Calvert formula, are discussed. This formula can be used to calculate the carboplatin dose accurately in order to obtain a target AUC by using only the GFR. The formula is: dose (mg) = AUC (mg ml-1 min) x [GFR (ml/min) + 25 (ml/min)].
What is Cmax and AUC?
In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.
How do you calculate AUC in Excel?
The formula for calculating the AUC (cell H18) is =SUM(H7:H17).